Treatment of Type I Diabetes using Autologous Adipose Derived Mesenchymal Stem Cells Translated to Insulin Secreting Islet like Cell Aggregates

摘要

Background: A number of papers describe different stem cell lines as the presenting feature to treat diabetes. Case Report: We report a 21 year old female with type 1 diabetes mellitus who was treated with islet like cell aggregates (ICAs) translated from autologous adipose derived mesenchymal stem cells (ADMSCs). Half of the total count of autologous adipose-derived stromal vascular fraction (AD-SVF) was injected intramuscularly. The other half was purified to ADMSCs and translated to ICAs and injected by intra-hepatic route. The patient showed remarkable decrease in her insulin requirement. No side effects were noted related to the treatment. Conclusion: The case study suggests AD-SVF and ADMSCs translated to ICAs is effective alternative strategy for the treatment of juvenile diabetes.