Ischemic Modified Albumin Predicts Critical Coronary Artery Disease in Unstable Angina Pectoris and Non-ST-Elevation Myocardial Infarction

摘要

Background: In this study, whether ischemia modified albumin (IMA) has a role in showing severity or criticality of coronary arteries in patients with unstable angina pectoris (USAP)on-ST-elevation myocardial infarction (NSTEMI) was assessed.Methods: A total of 65 patients (40 male (M) and 25 female (F) patients; mean age 59.7 ± 12.1 years) with the initial diagnosis of USAP/NSTEMI were included in this study. The levels of IMA, troponin T, creatine kinase MB (CK-MB), C-reactive protein (CRP), brain natriuretic peptide (BNP), creatinine, lipid panel, and whole blood count were measured from venous blood obtained from each patient within 3 h after the onset of symptoms. A 50% or greater coronary lumen stenosis of any coronary vessel or lateral branch was considered as critical stenosis. The severity of coronary artery disease (CAD) was assessed using the Gensini scoring system.Results: IMA was significantly higher in patients with critical coronary artery stenosis (median, 206 vs. 23; P < 0.001). There was a weak correlation between the Gensini score and IMA; whereas there was a moderate correlation between the Gensini score and BNP levels (r = 0.44, P = 0.02).Conclusion: The level of IMA can predict the criticality of CAD; however, it cannot predict the severity of CAD according to Gensini score in patients with USAP/NSTEMI.J Clin Med Res. 2018;10(7):570-575doi: https://doi.org/10.14740/jocmr3417w.