A game of musical chairs: Pro- and anti-resection factors compete for TOPBP1 binding after DNA damage

摘要

DNA double strand breaks (DSBs) are generally repaired through nonhomologous end joining or homologous recombination. In this issue, Liu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607031) report that the conserved scaffold protein TOPBP1~(Dpb11) provides binding sites for both pro- and anti-resection factors at DSBs, providing insights into repair pathway regulation.