Stardust, the Janus-faced partner of Crumbs

摘要

The Drosophila melanogaster scaffolding protein Stardust (Sdt) stabilizes the transmembrane protein Crumbs, a conserved regulator of apical–basal epithelial polarity. In this issue, Perez-Mockus et al. (2017. J. Cell Biol . https://doi.org/10.1083/jcb.201611196) report that a subset of Sdt isoforms are targeted by the ubiquitin ligase Neuralized, thus fine tuning the endocytosis and activity of this apical determinant.