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Graph-based unsupervised feature selection and multiview clustering for microarray data

机译:基于图的无监督特征选择和微阵列数据多视图聚类

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A challenge in bioinformatics is to analyse volumes of gene expression data generated through microarray experiments and obtain useful information. Consequently, most microarray studies demand complex data analysis to infer biologically meaningful information from such high-throughput data. Selection of informative genes is an important data analysis step to identify a set of genes which can further help in finding the biological information embedded in microarray data, and thus assists in diagnosis, prognosis and treatment of the disease. In this article we present an unsupervised feature selection technique which attempts to address the goal of explorative data analysis, unfolding the multi-faceted nature of data. It focuses on extracting multiple clustering views considering the diversity of each view from high-dimensional data. We evaluated our technique on benchmark data sets and the experimental results indicates the potential and effectiveness of the proposed model in comparison to the traditional single view clustering models, as well as other existing methods used in the literature for the studied datasets.
机译:生物信息学的一个挑战是分析通过微阵列实验产生的大量基因表达数据并获得有用的信息。因此,大多数微阵列研究要求进行复杂的数据分析,才能从此类高通量数据中推断出生物学上有意义的信息。信息基因的选择是鉴定一组基因的重要数据分析步骤,这些基因可以进一步帮助找到嵌入微阵列数据的生物学信息,从而有助于疾病的诊断,预后和治疗。在本文中,我们提出了一种无监督的特征选择技术,该技术试图解决探索性数据分析的目标,从而展现数据的多面性。考虑从高维数据中每个视图的多样性,它着重于提取多个聚类视图。我们在基准数据集上评估了我们的技术,实验结果表明,与传统的单视图聚类模型以及文献中用于研究数据集的其他现有方法相比,该模型的潜力和有效性。

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