Detection of high risk human papillomavirus types 16 and 18 in immune competent Egyptian patients with plantar and genital warts

摘要

Objectives: Human papilloma viruses have been identified in cutaneous and genital warts with minimal reports targeting, in particular, the association of high risk HPV-16 and 18 in Egyptian patients with genital warts, together with the absence of studies investigating these 2 viruses in plantar warts. Aim: To assess the impact of the virus type and investigate the association of high risk HPV-16 and 18 in plantar and genital warts of immune competent Egyptian patients. Patients and Methods: Fifty four Egyptian patients (33 with plantar warts and 21 with genital warts) were randomly included in this work. Highly sensitive polymerase chain reaction (PCR) with two different set of primers was used for the detection of each of the highly oncogenic potential viruses HPV-16 and HPV-18. Results: Both high risk HPV-16 and 18 were detected in two patients with plantar warts using the two different set of primers. The incidence of presence of HPV-16 and18 in genital warts was six times higher than that of plantar warts with a statistically significant difference between both groups (P- value< 0.05). Conclusion: This is the first study to detect high risk HPV-16 and 18 in plantar warts in Egyptian patients. The percentage of these viruses in genital warts was higher than reports by previous studies in literature.