Stereospecific Degradation of Diastereomers by Plant Associated Bacteria Influences the Antifungal Performance of Dodemorph

摘要

Morpholine fungcides have certain antibacterial side effect, dodemorph being the most active among them. The diequatorial ( style="font-family:Verdana;">cis style="font-family:Verdana;">- style="font-family:Verdana;">)? style="font-family:""> style="font-family:Verdana;">form of dodemorph expressed higher antibacterial activity than the axial-equatorial ( style="font-family:Verdana;">trans style="font-family:Verdana;">- style="font-family:Verdana;">)? style="font-family:Verdana;">form, and no synergy in their joint action could be revealed in this respect. Moreover, the partition of diastereomers between cells and medium strictly correlated to their toxicity. style="font-family:Verdana;">? style="font-family:""> style="font-family:Verdana;">Considerable differences were detected among degradation rates in various bacteria, and the? style="font-family:Verdana;">meso- style="font-family:Verdana;">( style="font-family:Verdana;">RS style="font-family:Verdana;">)-diastereomer was deteriorated more intensively, then the? style="font-family:Verdana;">trans style="font-family:Verdana;">-( style="font-family:Verdana;">SS style="font-family:Verdana;">?a style="font-family:Verdana;">n style="font-family:""> style="font-family:Verdana;">d? style="font-family:Verdana;">RR style="font-family:Verdana;">)-forms in? style="font-family:Verdana;">Corynebacterium style="font-family:Verdana;">? style="font-family:Verdana;">betae style="font-family:Verdana;">,? style="font-family:Verdana;">Erwinia uredovora? style="font-family:Verdana;">and? style="font-family:Verdana;">Pseudomonas style="font-family:Verdana;">fluorescens style="font-family:Verdana;">. As a result, the stereospecific degradation of diastereomers changed their ratio in the medium, thus this metabolic step c style="font-family:Verdana;">ould style="font-family:Verdana;">?influence the antifungal performance of dodemorph based preparations against filamentous fungi. It was demonstrated that due to synergic joint action style="font-family:Verdana;">, style="font-family:""> style="font-family:Verdana;">?the fungistatic effect of morpholine derivatives noticeably increased against? style="font-family:Verdana;">Botrytis cinerea style="font-family:Verdana;">?by changing the ratio of diastereomers.