Selinexor, a selective inhibitor of nuclear export (SINE), shows enhanced activity in combination with PD-1/PD-L1 blockade in syngeneic murine models of colon cancer and melanoma

Matthew R Farren; Reena Shakya; Rebecca Hennessey; Thomas Mace; Jennifer Yang; Omar Elnaggar; Gregory Young; Yosef Landesman; Robert Carlson; Sivan Elloul; Marsha Crochiere; Christin Burd; Gregory Lesinski

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Selinexor, a selective inhibitor of nuclear export (SINE), shows enhanced activity in combination with PD-1/PD-L1 blockade in syngeneic murine models of colon cancer and melanoma

机译：Selinexor是一种选择性的核输出抑制剂（SINE），在结肠癌和黑色素瘤的同系鼠模型中，与PD-1 / PD-L1阻滞剂结合使用显示出增强的活性

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来源
《Journal for ImmunoTherapy of Cancer》 |2015年第s2期|共页
作者
Matthew R Farren; Reena Shakya; Rebecca Hennessey; Thomas Mace; Jennifer Yang; Omar Elnaggar; Gregory Young; Yosef Landesman; Robert Carlson; Sivan Elloul; Marsha Crochiere; Christin Burd; Gregory Lesinski;
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中图分类肿瘤学;
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1. Phase II Results of Ara-C and Idarubicin in Combination with the Selective Inhibitor of Nuclear Export (SINE) Compound Selinexor (KPT-330) in Patients with Relapsed or Refractory AML [J] . Fiedler Walter, Heuser Michael, Chromik Joerg, Blood: The Journal of the American Society of Hematology . 2016,第22期

机译：ARA-C和IDARUBICIN的II期结果与复发或难治性AML复发或难治的AML患者的核促进（正弦）复合塞米松（KPT-330）的选择性抑制剂组合
2. Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone [J] . Muqbil Irfana, Aboukameel Amro, Elloul Sivan, Cancer letters . 2016,第2期

机译：通过与mTOR抑制剂和地塞米松联合使用，在非霍奇金淋巴瘤中增强了核输出（SINE）选择性抑制剂的抗肿瘤活性
3. TOPICAL SELINEXOR (KPT-330), A SELECTIVE INHIBITOR OF NUCLEAR EXPORT (SINE) SHOWS INCREASED BLOOD FLOW AND ACCELERATED HEALING USING NONINVASIVE TECHNIQUES IN AN ISCHEMIC MODEL OF WOUND HEALING [J] . Ganesh K., Kitsos C., Rashal T., Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society . 2015,第2期

机译：局部SELINEXOR（KPT-330），一种核出口的选择性抑制剂（正弦波），在创伤愈合的局部缺血模型中，使用非侵入性技术显示了血流量增加和愈合加快
4. α_vβ_3 INTEGRIN-TARGETED LIPOSOMES CONTAINING DOXORUBICIN INHIBIT TUMOR GROWTH AND ANGIOGENESIS IN A SYNGENEIC MURINE MELANOMA MODEL [C] . Charles A. Wartchow, Neal E. DeChene, S. Narasimhan Danthi, Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

机译：含阿霉素抑制肿瘤生长和血管生成的α_vβ_3整合素靶向脂质体在共性鼠黑素瘤模型中的应用
5. MFG-E8 Blockade Enhances Tumor Immunity in a Murine Breast Cancer Model. [D] . Draganov, Dobrin Draganov. 2012

机译：MFG-E8阻断增强鼠乳腺癌模型的肿瘤免疫力。
6. Selinexor a selective inhibitor of nuclear export (SINE) shows enhanced activity in combination with PD-1/PD-L1 blockade in syngeneic murine models of colon cancer and melanoma [O] . Matthew R Farren, Reena Shakya, Rebecca Hennessey, 2015

机译：Selinexor是一种选择性的核输出抑制剂（SINE）在结肠癌和黑色素瘤的同系鼠模型中与PD-1 / PD-L1阻滞剂结合使用显示出增强的活性
7. Selinexor, a selective inhibitor of nuclear export (SINE), shows enhanced activity in combination with PD-1/PD-L1 blockade in syngeneic murine models of colon cancer and melanoma [O] . Matthew R Farren, Reena Shakya, Rebecca Hennessey, 2015

机译：Selinexor是一种选择性的核输出抑制剂（SINE），在结肠癌和黑色素瘤的同系鼠模型中，与PD-1 / PD-L1阻滞剂结合使用显示出增强的活性

Selinexor, a selective inhibitor of nuclear export (SINE), shows enhanced activity in combination with PD-1/PD-L1 blockade in syngeneic murine models of colon cancer and melanoma

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