Correlations of Serum Chemerin and Visfatin with other Biochemical Parameters in Iraqi Individuals with Metabolic Syndrome and Type Two Diabetes Mellitus

摘要

Chemerin and visfatin are bioactive molecules that regulate numerous physiological functions such as energy equilibrium,insulin action, inflammatory response and vascular homeostasis. The objective of this study is to determine the correlationbetween serum chemerin and visfatin with other biochemical parameters in Iraqi patients with metabolic syndrome (MetS)and type 2 diabetes mellitus (T2DM). Twenty-two participants with MetS, forty-four with T2DM and twenty-two healthysubjects were recruited in this study. Serum concentrations of chemerin and visfatin, hs-CRP, fasting plasma glucose (FPG),fasting serum insulin (FSI), lipid profile for all participants were measured. Their correlations with the anthropometricparameters, insulin resistance and MetS parameters were specified. The results revealed that the MetS group has the highestserum levels of chemerin and hs-CRP compared to T2DM and the control groups (151.77±10.43 ng/mL, 129.36±5.03 ng/mLand 63.98±14.74ng/mL respectively) with significant difference of (P0.001) and (8.1±1.1mg/L, 7.96±1.18mg/L and4.55±2.31mg/L respectively). Visfatin serum concentration was higher in the T2DM group than that of the MetS and controlgroup (63.71±8.30ng/mL, 56.03±10.58 ng/mL and 52.46±14.05 ng/mL respectively). Both of these two adipokines werefound to be correlated with some parameters. Moreover, no correlation was found between the two proteins. From theobtained results we concluded that the assessment of chemerin and visfatin levels and their relation to some metabolicparameters can help to identify subjects who are more susceptible to the cardiovascular disease (CVD risk.