Echocardiographic Findings In Thalassemia Major Patients: An Experience From Jammu Oropharyngeal Topical 10% Xylocaine Spray Before Induction of Anaesthesia in Attenuating the Pressor Response to Direct Laryngoscopy and Endotracheal Intubation

摘要

Current Study was done to assess the echocardigraphic changes in Thalassemia Major patients. AllThalassemic Major patients above 10 years of age registered with Thalassemia day care centre at SMGShospital, Government Medical College Jammu with normal electrocardiogram and no clinical features ofheart failure were included in this retrospective study. Their medical records were analyzed in terms ofage, gender, average hemoglobin levels, serum ferritin levels and echocardiographic findings. 95 patientswho were more than 10 years of age and had normal electrocardiogram and no clinical features of heartfailure were included in this study. Out of these 95 patients 55 showed abnormal findings onechocardiography. All patients except one showed normal systolic function. Echocardiography in 54 patientsshowed only diastolic dysfunction and one had tricuspid regurgitation (TR) in addition . 55 Thalassemiamajor patients with abnormal echocardiographic findings comprised of 30 males and 25 females. All thepatients in the age group of more than 20 years and 12 patients in the age group of 10 years to 20 yearsshowed abnormal echocardiographic findings. Average hemoglobin and serum ferritin in these childrenwere around 5-7gms /dl and more than 3000 ng/ml respectively. Echocardiographic findings suggestive ofleft ventricular diastolic dysfunction were the commonest findings indicating early cardiac dysfunction inpatients with Thalassemia major in 2nd and 3rd decade of their life.