Inhibitory Effects of a Novel Synthetic Protease Inhibitor, FUT-175, on the Paw Edema in Rats and Zymosan-induced Complement Activation in Vitro

摘要

References(9) Cited-By(1) FUT-175 inhibited the zymosan-induced rat paw edema in a dosedependent manner, while indomethacin exhibited no significant activities in this model. FUT-175 also inhibited the decrease in hemolytic complement (CH50) induced by zymosan in vitro, and indomethacin was inactive. These results suggest that FUT-175 has potent in vitro and in vivo inhibitory activity against the activation of the complement system induced by zymosan.