THE EFFECTS OF DRUGS ON THE MEMBRANE ACTIVITIES OF THE TOAD SARTORIUS MUSCLE

摘要

References(19) 1. The effects on the membrane activities of the toad sartorius muscle of veratrine, aconitine, veriloid, calcium-free solution, guanidine, TEA, quinine, caffeine, excess of K+ ion, procaine and CuO+ ion were investigated with an intracellular recording electrode.2. Veratrine produced repetitive muscle spikes when single shock stimulation was applied either to the nerve or muscle.Veriloid, aconitine and calcium-free solution have been observed to produce such repetitive responses.Guanidine produced repetitive muscle spikes only if a motor nerve volley was applied.3. Veratrine, aconitine, veriloid, guanidine, quinine, TEA and procaine did not alter the resting potential. Excess of K+ ion, caffeine and CuO+ ion produced a marked fall in the resting potential.4. Veratrine, aconitine, TEA and guanidine increased the size of the e.p.p. in the low-sodium muscle, whereas caffeine, quinine, veriloid and CuO+ ion decreased it. Procaine was ineffective or only slightly diminished the size.