References(8) Cited-By(3) Dextromethorphan, dimemorfan, dihydrocodeine and oxymethebanol, centrally acting antitussives, were examined for their effect on Ehrlich carcinoma cells and sarcoma-180 cells in vitro or in vivo. The tumor cells were suspended in Hanks balanced salt solution (pH 7.4) supplemented with 2% bovine albumin, and they were incubated with and without 1 mM drugs at 37°C for 120 min. The incubation of the tumor cells with dextromethorphan or dimemorfan resulted in a decrease in the proportion of the viable cells (less than 25% after 120 min). However, no significant change was observed in the proportion of the viable tumor cells during the incubation with and without the other drugs (80-83% after 120 min). In addition, mice given the tumor cells i.p. were injected intraperitoneally with drugs (20-80 mg/kg/day) once daily for 5 successive days, and their survival time was observed. There was a slight difference in the survival time between mice treated with and without dextromethorphan or dimemorfan. However, a significant difference was found in the survival time between mice treated with and without dextromethorphan when mice given Ehrlich carcinoma cells were injected with the drug (40 mg/kg/time) twice a day for 5 days (about 18 days and 29 days). These results indicate that dextromethorphan and dimemorfan are cytotoxic to the tumor cells in vitro and in vivo.
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机译：参考文献（8）被引用的By（3）右美沙芬，二甲美沙芬，二氢可待因和羟甲基苯乙醇，为中枢镇咳药，研究了它们在体外或体内对Ehrlich癌细胞和肉瘤180细胞的作用。将肿瘤细胞悬浮在补充有2％牛白蛋白的汉克斯平衡盐溶液（pH 7.4）中，将它们与含或不含1 mM的药物在37°C下孵育120分钟。将肿瘤细胞与右美沙芬或二甲美沙芬一起孵育会导致活细胞比例降低（120分钟后小于25％）。然而，在有或没有其他药物的温育过程中，存活的肿瘤细胞的比例没有观察到显着变化（120分钟后为80-83％）。另外，给小鼠腹腔注射肿瘤细胞。连续5天每天一次腹膜内注射药物（20-80 mg / kg /天），观察其存活时间。在使用和未使用右美沙芬或地美莫芬治疗的小鼠之间，存活时间略有差异。但是，当每天两次给给予Ehrlich癌细胞的小鼠注射药物（40 mg / kg /次）连续5天（约18天和29天）时，发现在使用和未使用右美沙芬的小鼠之间的存活时间存在显着差异。 ）。这些结果表明右美沙芬和二甲美沙芬在体外和体内对肿瘤细胞具有细胞毒性。
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