Cardiovascular Effects of an Ionophorous Antibiotic, Lonomycin A, in Anesthetized Dogs

摘要

References(19) Cited-By(2) An intracoronary administration of lonomycin A, a K-selective ionophore, produced coronary vasodilatation in the presence of pindolol in anesthetized dogs. Coronary vasodilatation induced by lonomycin A, KCl and nifedipine was inhibited by pretreatment with an intracoronary injection of ouabain. This result suggests that lonomycin A-induced coronary vasodilatation may be partly due to a stimulation of Na+, K+-ATPase as well as KCl and/or a decrease in Ca2+ influx as well as nifedipine.