Antimicrobial and anticholinesterase activities of the essential oils isolated from Salvia dicroantha Stapf., Salvia verticillata L. subsp. amasiaca (Freyn and Bornm.) Bornm. and Salvia wiedemannii Boiss.

摘要

In this study, the essential oil compositions and antimicrobial and anticholinesterase activities of three Turkish endemicSalviaspecies were investigated. Thegas chromatography(GC) andgas chromatography -mass spectrometry(GC-MS) analysis of the essential oils obtained fromSalvia dicroantha, Salvia verticillatasubsp.amasiaca,andSalvia wiedemanniishowed that the major constituents were caryophyllene oxide (22.4%), Germacrene D (36.6%), and α-pinene (36.2%), respectively. All essential oils exhibited antimicrobial activity against tested Gram-positive and Gram-negative bacteria, and test yeast strains. The minimum inhibitory concentrations (MICs) of oils ranged from 12.5 to 50.0 µl/ml.Additionally, essential oils were more active than standard antifungals, inhibiting test strains of yeasts such asCandida albicans, Candida glabrata,andSaccharomyces cerevisiae.At 400 µM concentration, theessential oil ofS. wiedemanniihad moderate acetylcholinesterase (55.95±2.01%), and butyrylcholinesterase (50.97±3.12%) inhibitoryactivity, while other two species no activity against both enzymes.