Wanted: New Excipients to Meet the Demands of a Challenging Industry

摘要

Current trends in the pharma market, such as the discovery of increasingly lipophilic APIs, macromolecules, andbiological actives have created a need for a more in-depth understanding of existing excipients, as well as the creationof new excipients, says Karen A. Coppens, Global Marketing Manager for Dow. “For example, there are few excipients that are designed for processes such as hot melt extrusion or spray drying to enable solubility enhancement ofhighly lipophilic insoluble APIs,” she says. As such, a number of new products have been introduced that are modifications of existing monographed excipients.