Design, synthesis and biological evaluation of benzoxazole derivatives as new anti-inflammatory agents

摘要

New series of N-(5-(5-(Alkylthio)-1,3,4-oxadiazol-2-yl)benzoxazol-2-yl)benzamide derivatives(VI) were synthesized by the reaction of N-(5-(5-mercapto-1,3,4-oxadiazol-2-yl)benzooxazol-2-yl) benzamides with appropriate alkyl halides. The chemical structures of the synthesized compounds were confirmed by means of IR, 1HNMR, Mass spectral analysis. Further, the synthesized compounds (VIa-VIl) were screened for antiinflammatory activity by using Carrageenan-induced paw edema rat model. The results showed that, compounds VId, VIe, VIf and VIh were significantly (p0.0001) reduced the inflammation there by showed a promising anti-inflammatory activity; where as the compound VIb, VIg and VIi moderately reduced the inflammation. The compounds VIa, VIc, VIj, VIk and VIl showed very poor anti-inflammatory activity towards Carrageenan-induced paw edema rat.