A Comparative Study of Platelet Parameters in Chronic Kidney Disease, End Stage Renal Disease Patients Undergoing Hemodialysis and Healthy Individuals

摘要

Background: With the rising trend of diabetes mellitus and hypertension, there is also a rise in chronic complications like chronic kidney disease (CKD) and end stage renal disease (ESRD). Cardiovascular complications remain the most common cause of death among ESRD patients and those on hemodialysis (HD). Hemodialysis patients behave in a distinct way that they are relatively more prone for bleeding than thrombotic manifestations. In recent days, abnormalities in platelet parameters are found to be an effective tool in risk stratification of patients with chronic kidney disease (CKD) to develop coronary artery disease. Platelet parameters are considered as inflammatory markers. The present study was taken to find the association of various platelet parameters among hemodialysis patients and CKD patients. Objectives: The aim was to study the platelet distribution width (PDW), mean platelet volume (MPV), plateletcrit (PCT) and platelet large cell ratio (PLCR) among ESRD patients undergoing maintenance hemodialysis and compare with CKD patients and healthy age and sex matched controls. Methods: The present study was done on three groups. Group 1 included 20 healthy individuals from hospital staffs and healthy volunteers matched for age and sex, Group2 included 60 CKD patients and Group 3 included 40 ESRD patients on maintenance HD. Results: The mean values of platelet distribution width (PDW), mean platelet volume (MPV), platelet count, plateletcrit ratio (PCT) and platelet large cell ratio (P-LCR) were found to be higher in CKD and ESRD patients when compared to healthy controls. PDW, PCT and L-PCR attained statistical significance, while MPV did not. Conclusions: Abnormality in platelet parameters can be used as a predictor of underlying inflammation and severity of atherosclerosis as all these parameters are lesser than that observed in control population.