Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeys

Y. Saisho; A. E. Butler; E. Manesso; R. Galasso; L. Zhang; T. Gurlo; G. M. Toffolo; C. Cobelli; K. Kavanagh; J. D. Wagner; P. C. Butler

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Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeys

机译：猴子胰岛β细胞面积分数与空腹血浆葡萄糖浓度的关系

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Aims/hypothesis We sought to establish the relationship between fasting plasma glucose concentrations and pancreatic fractional beta cell area in adult cynomolgus monkeys (Macaca fascicularis). Methods Fasting plasma glucose and pancreatic fractional beta cell area were measured in 18 control and 17 streptozotocin-treated adult primates (17.0?±?1.2 vs 15.4?±?1.2?years old). Results Fasting plasma glucose was increased (12.0?±?2.0 vs 3.4?±?0.1?mmol/l, p?p?

机译：目的/假设我们试图建立空腹血浆葡萄糖浓度与成年食蟹猴（猕猴）的胰岛式β细胞面积之间的关系。方法在18例对照和17例链脲佐菌素处理的成年灵长类动物（17.0？±1.2）岁和15.4？±1.2？岁）中测量空腹血糖和胰腺β细胞面积。结果链脲佐菌素治疗的猴子的空腹血糖升高（12.0±±2.0，vs 3.4±0.1±0.1mmol / l，p <0.01）。空腹血糖与胰腺部分β细胞面积之间的关系由对照中多种β细胞面积描述。在用链脲佐菌素处理的猴子中，空腹血糖在对照组的平均β细胞面积的〜50％处发生增加，随着β细胞面积的进一步减少，血糖急剧增加。结论/解释在成年非人类灵长类动物中，β细胞分数的减少幅度达到〜50％或更高会导致血糖控制丧失。

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《Diabetologia: clinical and experimental diabetes and metabolism》 |2009年第1期|共4页
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Y. Saisho; A. E. Butler; E. Manesso; R. Galasso; L. Zhang; T. Gurlo; G. M. Toffolo; C. Cobelli; K. Kavanagh; J. D. Wagner; P. C. Butler;
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1. Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeys [J] . Y. Saisho, A. E. Butler, E. Manesso, Diabetologia . 2010,第1期

机译：猴子胰脏β细胞面积分数与空腹血浆葡萄糖浓度的关系
2. Evaluation of the relationship between the one-hour plasma glucose concentration and beta-cell functions and cardiometabolic parameters during oral glucose tolerance test in obese children and adolescents [J] . EdaMengen, Seyit AhmetU?aktürk Journal of pediatric endocrinology & metabolism: JPEM . 2020,第6期

机译：肥胖儿童及青少年口腔葡萄糖耐量试验期间1小时血浆葡萄糖浓度及β细胞功能与心肌酶参数的关系
3. Relationship between the level of fasting plasma glucose and beta cell functions in Chinese with or without diabetes [J] . PANG Can, BAO Yu-qian, WANG Chen, 中华医学杂志（英文版） . 2008,第021期

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4. A novel bioelectronic glucose sensor to process distinct electrical activities of pancreatic beta-cells [C] . Nguyen, Quang Vinh, Caro, Anton, Raoux, Matthieu, Annual Conference of Japanese Society for Medical and Biological Engineering;Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2013

机译：一种新颖的生物电子葡萄糖传感器，可处理胰腺β细胞的独特电活动
5. The Short Chain Fatty Acid Receptor, Free Fatty Acid-2 Receptor (FFA2), Contributes to Gestational Glucose Homeostasis through a Novel Relationship Between Pancreatic Beta Cells, Short Chain Fatty Acids and the Gut Microbiota. [D] . Fuller, Miles Henry. 2016

机译：短链脂肪酸受体，游离脂肪酸2受体（FFA2）通过胰腺β细胞，短链脂肪酸和肠道菌群之间的新关系，有助于妊娠期葡萄糖体内稳态。
6. Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeys [O] . Y. Saisho, A. E. Butler, E. Manesso, -1

机译：猴子胰脏β细胞面积分数与空腹血浆葡萄糖浓度的关系
7. Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeys. [O] . SAISHO Y, BUTLER AE, MANESSO E, 2010

机译：猴子的胰岛部分β细胞面积与空腹血糖浓度之间的关系。

Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeys

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