首页> 外文期刊>Dermatology and Therapy >An Open-Label, Intra-Individual Study to Evaluate a Regimen of Three Cosmetic Products Combined with Medical Treatment of Rosacea: Cutaneous Tolerability and Effect on Hydration
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An Open-Label, Intra-Individual Study to Evaluate a Regimen of Three Cosmetic Products Combined with Medical Treatment of Rosacea: Cutaneous Tolerability and Effect on Hydration

机译:一项开放性,内部个体研究,评估三种化妆品与酒渣鼻的治疗相结合的方案:皮肤耐受性和对水合作用的影响

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IntroductionAlthough rosacea management includes general skincare, previous studies have not evaluated comprehensive skincare regimens as adjuvants to other treatments. MethodsThe primary objective of this open-label, intra-individual study of subjects with rosacea was to evaluate the cutaneous tolerability of a regimen consisting of Cetaphil PRO Redness Control Day Moisturizing Cream (once daily in the morning), Cetaphil PRO Redness Control Night Repair Cream (once daily in the evening) and Cetaphil PRO Redness Control Facial Wash (foam once in the morning and once in the evening). Secondary objectives were to evaluate the effect on transepidermal water loss (TEWL) and cutaneous hydration and to determine the subjects’ evaluation of efficacy, tolerability and future use. A dermatologist examined subjects and measured TEWL and cutaneous hydration on day (D) 0, D7 and D21, when subjects ranked symptoms. Subjects completed a questionnaire on D21. ResultsThe per-protocol population consisted of 42 subjects receiving treatment for rosacea. Eleven subjects developed adverse events, none of which were considered to be related to the skincare products. Five subjects showed signs or symptoms that were potentially associated with the skincare products that might suggest poor cutaneous tolerability; these were generally mild. TEWL decreased significantly by a mean of 17% on D7 and a mean of 28% on D21 compared with baseline (both P ?0.001). Skin hydration increased significantly by a mean of 5% on D7 ( P =?0.008) and a mean of 10% on D21 ( P ?0.001) compared with baseline. Subjects reported that the regimen was pleasant (98%) and effective (95%) and that it offered various benefits; 90% of subjects reported that they would like to continue to use the regimen and would buy the products. ConclusionThe skincare regimen improved skin hydration and skin barrier function in subjects receiving medical treatment for rosacea and was well tolerated. FundingGalderma S.A.
机译:引言尽管酒渣鼻的治疗包括一般的皮肤护理,但先前的研究尚未评估综合的皮肤护理方案作为其他治疗的佐剂。方法这项开放式个体内研究酒渣鼻的主要目标是评估由Cetaphil PRO泛红控制日保湿霜(每天一次),Cetaphil PRO泛红控制夜间修护霜组成的方案的皮肤耐受性(每天晚上一次)和Cetaphil PRO Redness Control洗面奶(早上一次和晚上一次)。次要目的是评估对表皮失水(TEWL)和皮肤水合作用的影响,并确定受试者对疗效,耐受性和未来用途的评估。皮肤科医生对受试者进行了检查,并在受试者对症状进行排名的第(D)0,D7和D21天测量了TEWL和皮肤水合。受试者完成了关于D21的问卷。结果按方案人群包括接受酒渣鼻治疗的42名受试者。十一名受试者发生了不良事件,没有一个被认为与护肤产品有关。五名受试者表现出与护肤品潜在相关的体征或症状,可能表明其皮肤耐受性差。这些通常是温和的。与基线相比,TEWL在D7时平均下降了17%,在D21时平均下降了28%(均P <?0.001)。与基线相比,D7皮肤的水合作用显着增加了5%(P = 0.008),D21显着增加了10%(P <0.001)。受试者报告说,该方案令人愉快(98%)和有效(95%),并且具有多种益处。 90%的受试者报告说他们想继续使用该疗法并愿意购买该产品。结论皮肤护理方案改善了酒渣鼻患者的皮肤水分和皮肤屏障功能,并且耐受性良好。资金Galderma S.A.

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