Multiple subcutaneous granulomas after poly- l-lactic acid (Sculptra) injections

摘要

Poly- L -lactic acid (PLA; Sculptra; Dermik Laboratories, Berwyn,PA, USA) was introduced in 2004 for the treatment of facial lipoa-trophy associated with human immunodeficiency virus. Later, itgained popularity as a cosmetic volumizer for soft-tissue enhance-ment in the general population. 1 Overall, PLA injections are associ-ated with low complication rates. Self-limited, short-termcomplications include bruising and edema. Long-term complica-tions such as clinically visible papules and subcutaneous nodulesat the injection site have also been reported. 1–7 Herein, we presenta case of multiple subcutaneous granulomas formation, which wasconfirmed by histopathological analysis, in an immunocompetentpatient who received PLA injections for soft-tissue cosmeticenhancement.