Formulation and optimization of orodispersible tablets containingan antidepressant

摘要

Venlafaxine hydrochloride is used in the treatment of depression and anxiety disorders. The objective of the present study was to prepare the orodispersible tablets of venlafaxine hydrochloride by sublimation method. Camphor and menthol are used as subliming agents. Tablets are prepared by direct compression process with calcium silicate and sodium starch glycolate as super disintegrants and mannitol as bulking agent. The prepared tablets were evaluated for hardness, friability, in vitro dispersion time, weight uniformity, wetting time and for in vitro drug release. Further the tablets were characterized by Fourier Transform Infra Red Spectroscopy and by Differential Scanning Calorimetry. Sublimation of camphor from tablets resulted in superior tablets as compared with tablets prepared with menthol as sublimating agent. Among all the formulations the tablets prepared by sublimating camphor with sodium starch glycolate as super disintegrant showed faster disintegration and rapid drug release.