Calciphylaxis, also known as calcific uremic arteriolopathy, is a rare, but often fatal condition involving vascular calcification that can result in tissue ischemia and cutaneous necrosis. It is most often seen in patients with renal failure among many other occasionally reported etiologies. Below, we present a rare and challenging case of calciphylaxis involving the glans penis and right leg in a man with end stage renal disease on hemodialysis.
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