ESTROGEN RECEPTOR ALPHA EXPRESSION AND LIVER FIBROSIS IN CHRONIC HEPATITIS C VIRUS GENOTYPE 1B: A CLINICOPATHOLOGICAL STUDY

摘要

Background: Hepatic damage due to chronic hepatitis C virus (HCV) genotype 1b infection varies widely. Objectives: We aimed to investigate whether estrogen receptor alpha (ER?) plays a role in liver fibrosis in patients infected with HCV genotype 1b.Patients and Methods: All the consecutive patients who received the same standard treatment protocol for HCV genotype 1b were subdivided into two subgroups according to their fibrosis scores as fibrotic stagesResults: There were 66 patients in the mild fibrosis group and 24 in the advanced fibrosis group. Among the mild and advanced fibrosis groups, 65.1% and 50%were female, respectively (P=0.19). There was an inverse correlation between ER? and fibrotic stage (r: -0.413; P Conclusions: ER? expression in liver was inversely correlated with liver fibrosis among patients infected with chronic HCV genotype 1b.