Inhibition of fluid phase and clot-bound thrombin by the thrombin exosite I ligand LU 58463: comparison with heparin and hirudin | Haematologica

E Filippucci; G Agnelli; M Leone; GG Nenci

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Inhibition of fluid phase and clot-bound thrombin by the thrombin exosite I ligand LU 58463: comparison with heparin and hirudin | Haematologica

机译：凝血酶外位I配体LU 58463对液相和凝块结合的凝血酶的抑制作用：与肝素和水rud素的比较|血液学

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《Haematologica》 |2002年第10期|共2页
作者
E Filippucci; G Agnelli; M Leone; GG Nenci;
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中图分类血液及淋巴系疾病;
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1. Effect of heparin on TAFI-dependent inhibition of fibrinolysis: relative importance of TAFIa generated by clot-bound and fluid phase thrombin. [J] . Colucci M, Pentimone A, Binetti BM, Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 2002,第2期

机译：肝素对TAFI依赖性纤溶抑制的影响：凝块结合和液相凝血酶产生的TAFIa的相对重要性。
2. Low molecular weight heparins prevent thrombin-induced thrombo-embolism in mice despite low anti-thrombin activity. Evidence that the inhibition of feed-back activation of thrombin generation confers safety advantages over direct thrombin inhibition | Haematologica [J] . S Momi, M Nasimi, M Colucci, Haematologica . 2001,第3期

机译：尽管抗凝血酶活性较低，但低分子量肝素仍可预防小鼠凝血酶诱导的血栓栓塞。与直接抑制凝血酶相比，抑制凝血酶产生的反馈激活具有安全优势的证据血液学
3. Ligand binding to thrombin exosite II induces dissociation of the thrombin-heparin cofactor II(L444R) complex [J] . Han JH., Tollefsen DM. Biochemistry . 1998,第9期

机译：配体与凝血酶异位点II的结合诱导凝血酶-肝素辅因子II（L444R）复合物的解离
4. Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors. [O] . J I Weitz, M Hudoba, D Massel, 1990

机译：凝块结合的凝血酶受到保护不会被肝素-抗凝血酶III抑制但容易受到抗凝血酶III依赖性抑制剂的灭活作用。
5. Effects of thrombin inhibition on the development of acute platelet-thrombus deposition during angioplasty in pigs. Heparin versus recombinant hirudin, a specific thrombin inhibitor. [O] . M Heras, J H Chesebro, W J Penny, 1989

机译：凝血酶抑制对猪血管成形术期间急性血小板血栓沉积的影响。肝素与重组血红蛋白，特定凝血酶抑制剂。

Inhibition of fluid phase and clot-bound thrombin by the thrombin exosite I ligand LU 58463: comparison with heparin and hirudin | Haematologica

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