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首页> 外文期刊>Yonsei Medical Journal >Epigenetic Cross-Talk between DNA Methylation and Histone Modifications in Human Cancers
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Epigenetic Cross-Talk between DNA Methylation and Histone Modifications in Human Cancers

机译:人类癌症中DNA甲基化与组蛋白修饰之间的表观遗传学对话

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摘要

DNA methylation, histone modifications, and the chromatin structure are profoundly altered in human cancers. The silencing of cancer-related genes by these epigenetic regulators is recognized as a key mechanism in tumor formation. Recent findings revealed that DNA methylation and histone modifications appear to be linked to each other. However, it is not clearly understood how the formation of histone modifications may affect DNA methylation and which genes are relevantly involved with tumor formation. The presence of histone modifications does not always link to DNA methylation in human cancers, which suggests that another factor is required to connect these two epigenetic mechanisms. In this review, examples of studies that demonstrated the relationship between histone modifications and DNA methylation in human cancers are presented and the potential implications of these epigenetic mechanisms in human neoplasia are discussed.
机译:DNA甲基化,组蛋白修饰和染色质结构在人类癌症中发生了深远的变化。这些表观遗传调控因子使癌症相关基因沉默被认为是肿瘤形成的关键机制。最近的发现表明,DNA甲基化和组蛋白修饰似乎相互关联。但是,尚不清楚组蛋白修饰的形成如何影响DNA甲基化以及哪些基因与肿瘤形成相关。组蛋白修饰的存在并不总是与人类癌症中的DNA甲基化相关,这表明连接这两种表观遗传机制还需要另一个因素。在这篇综述中,研究实例证明了人类癌症中组蛋白修饰与DNA甲基化之间的关系,并讨论了这些表观遗传机制在人类肿瘤形成中的潜在意义。

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