LD50 in fish and rat produced by powdered roots of Derris spp and ecotoxicological implications

摘要

.- Mascaro U.C.P., Rodrigues L.A , Bastos J. K., Santos E. & Costa J.P.C. 1998. [LD50 in fish and rat produced by powdered roots of Derris spp and ecotoxicological implications.] Valores de DL50 em peixes e no rato tratados com p?3 de ra?-zes de Derris spp e suas implica?§?μes ecotoxicol?3gicas. Pesquisa Veterin??ria Brasileira 18(2):53-56. Faculdade de Ci?ancias Farmac?auticas de Ribeir?￡o Preto, USP, Via do Caf?? s, Ribeir?￡o Preto, SP 14040-903, Brazil. True "timb?3s" from the Brazilian Amazon region, plants belonging to the genus Derris of the Leguminosae family, have there considerable importance, because they contain rotenoids which are toxic to fish and mammals. The aim of the study was to establish the lethal doses (LD50) for three phylogenetical different species of fish and also for the rat. The lethal dose for Collosoma macropomum (tambaqui) was 2.6 mg/ml, for Oreochromis niloticus (til??pia) 4.8 mg/ml, for Plecostomus sp (cascudo) 14.2 mg/ml and for Rattus norvegicus 100 mg/kg. The large differences between the lethal doses for the fish and the one for the rat are possibly due to different barrier tissues against the action of rotenoids in the mammal when given orally. INDEX