?zet Yüksek konsantrasyonlar? toksik olan selenyum, eser element olarak vücut i?in esansiyeldir. Vücudumuzda bir ?ok enzimin kofakt?rüdür ve temel olarak antioksidan fonksiyonuyla bilinir. Selenyum, insanlarda organizmay? oksidatif hasarlardan koruyan glutatyon peroksidazlar?n, deiyodinazlar?n, tiyoredoksin redüktaz?n ve selenoprotein P? nin de dahil oldu?u pek metabolizmada rol oynamaktad?r. Selenyum iz element olarak inflamatuar, immunregülatuar ve endokrin fonksiyonlar?n düzenlenmesi i?in hem yap?sal ve hem de kofakt?r olarak rol al?r. Selenyumun baz? kanser tiplerine kar?? koruyucu olabilece?i, erkek fertilitesini art?rd???, kardiyovasküler mortalitede azalma sa?lad??? ve ast?mda inflamatuar mediat?rlerin yap?m?n? bask?lad??? g?sterilmi?tir. Selenyum ilk ara?t?rmalarda antikarsinojenik etkileri ile ilgi ?ekmi?tir. Daha sonra 1990? l? y?llarda tiroid hormon metabolizmas? üzerindeki etkileri ara?t?r?lmaya ba?lanm??t?r. Selenyumla ilgili yap?lan ?al??malar artt?k?a, dünyada ve Türkiye?de uzun y?llard?r devam eden iyot suplementasyonu yan?nda, sa?l?kl? ve bilinen tiroid patolojisi olan ki?ilere, ?zellikle gebelere selenyum suplemantasyonu yap?l?p yap?lmamas? gerekti?i giderek artan sorular aras?ndad?r. Biz bu sorulara daha iyi yan?t verebilmek amac?yla, literatürde tiroid hastal??? ile ilgili selenyum tedavisini i?eren yaz?lar?n analizini yapmaya ?al??t?k. Türk Jem 2010; 14: 76-9 Anahtar kelimeler: Tiroid, selenyum Abstract Selenium, which is toxic in high concentrations, is essential for the body. This trace element known for its antioxidant function is the cofactor of many enzymes. Selenium plays a role in many metabolic processes involving the enzymes glutathion peroxidases, deiodinases, thioredoxin reductases, and selenoprotein P that protect the organism from oxidative damages in humans. Selenium as a trace element plays role both structurally and as cofactor in the regulation of inflammatory processes, immune and endocrine functions. It has been shown that selenium may be a protector against some cancer types, increases male fertility, reduces cardiovascular mortality, and represses formation of inflammatory mediators in asthma. In first research studies, selenium drew attention with its anti-carcinogenic effects. Afterwards, its effects on thyroid hormone were started to be investigated in 1990s. As the studies on selenium increase, among the questions that frequently arise is whether to give selenium supplementation to healthy persons and patients with known thyroid pathology, especially to pregnant women, beside the iodine supplementation that has been used for a long time in the world and Turkey. In order to be able to give better answers to these questions, we tried to analyze the articles including selenium treatment related to thyroid disorders in the literature. Turk Jem 2010; 14: 76-9
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