Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity

摘要

Some pyridazine derivatives carrying urea, thiourea, andsulfonamide groups were synthesized and evaluated for theirantimicrobial activity against gram-positive and gram-negativebacteria, and fungi by using broth microdilution. The structures ofthese new compounds were confirmed by ^1H-NMR, mass spectrum, andelemental analysis. The synthesized compounds exhibited generallypromising inhibitory activity against S. aureus (MIC ranging from 2 to4 mu g/mL) and E. coli (MIC ranging from 4 to 16 mu g/mL).Moreover, all compounds showed antifungal activity against both C.albicans and C. parapsilosis, with a MIC value of 8 mu g/mL.