Three-component Passerini-Smiles coupling reaction of aldehydes and isocyanides with tropolone catalyzed by silica nanoparticles

摘要

The use of Smiles rearrangement in Passerini-type couplingswith tropolone allows very straightforward multicomponent formation oflpha-aryloxy amide derivatives. The 3-component addition ofisocyanide to tropolone (2-hydroxy-2,4,6-cycloheptatrien-1-one) andaldehyde in the presence of silica nanoparticles (silica NP, ca. 70nm) proceeds easily in methanol to form the title compounds in a newPasserini-Smiles-type reaction.