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Pulmonary inflammatory myofibroblastic tumor mimics lung cancer

机译:肺炎性肌纤维母细胞瘤模拟肺癌

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The term pulmonary inflammatory myofibroblastic tumor(IMT) has been adopted by theWorldHealth Organization torefer to a variety of pulmonary diseases previously namedinflammatory pseudotumor, plasma cell granuloma,fibroxanthoma, fibrous histiocytoma, pseudosarcomatousmyofibroblastic tumor, and invasive fibrous tumor of the tracheobronchialtree.1 Originally,IMT was regarded as a benigntumor, because its histological features included spindle cellproliferation, accompanied by prominent inflammatory cellinfiltration.2 Furthermore, this tumor had a response to nonsteroidalanti-inflammatory agent treatment. However, evidencehas suggested that IMT was a tumor of intermediatemalignant potential, including adjacent tissue invasion,metastasis,3 and genetic abnormalities.4 Therefore, it isimportant to differentiate IMT from pulmonary inflammatorypseudotumor or sarcoma for the development of therapeuticprotocol. To gain further knowledge about IMT, wewill discuss two cases with unusual characteristics.
机译:肺炎性肌纤维母细胞瘤(IMT)一词已被世界卫生组织采用,指的是先前被称为炎性假瘤,浆细胞肉芽肿,纤维状黄瘤,纤维组织细胞瘤,假性肉瘤性肌纤维母细胞瘤和气管支气管树的浸润性纤维瘤的多种肺部疾病。1被认为是良性肿瘤,因为其组织学特征包括纺锤体细胞增殖,并伴有明显的炎性细胞浸润。2此外,该肿瘤对非甾体类抗炎药治疗有反应。然而,有证据表明IMT是具有中等恶性潜能的肿瘤,包括邻近组织的侵袭,转移,3和遗传异常。4因此,将IMT与肺炎性伪肿瘤或肉瘤区分开来对于制定治疗方案具有重要意义。为了获得有关IMT的更多知识,我们将讨论两个具有不同特征的案例。

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