Association of angiotensin II levels in patients of vasovagal syncope and postural tachycardia syndrome.

摘要

Syncope occurs as a result of cerebral hypoperfusion. Various neuroendocrinehormones have some role in the pathogenesis of Syncope. Current study was conducted todetermine the role of Angiotensin II in pathophysiology of vasovagal syncope (VVS) and Posturaltachycardia syndrome (POTS). Study Design: Cross sectional analytical study. Setting: IslamicInternational Medical College, Rawalpindi and in Electrophysiology department (AFIC). Period:April 2017 to April 2018. Material and Methods: Sample size of this study was comprises of 80subjects, having 35 cases of VVS and POTS each and 10 controls were also taken. Cases werecollected on the basis of Head up tilt test (HUT) result and on their previous history of syncope,then their blood samples were collected and stored. Hormonal analysis of Angiotensin II wasperformed by ELISA technique. SPSS statistics 21 was used to evaluate result by applyingANOVA test. p value of 0.05 was considered significant. Result: Analysis of AngiotensinII concentration in Postural tachycardia syndrome, Vasovagal and control group was found170.93 ± 118.59 pg/ml, 152.16 ± 91.40 pg/ml and 136.93 ± 43.18 pg/ml respectively. Instatistical analysis p value was 0.570 which is insignificant. Conclusion: It is concluded thatAngiotensin II exerts role in the pathophysiology of VVS and POTS as shown by the differencein the value of Angiotensin II in VVS, POTS and in control group.