RELATIONSHIP OF CORONARY ARTERY DISEASE (CAD) WITH TOTAL CHOLESTEROL & LDL - HOLESTEROL/HDL-CHOLESTEROL RATIO

摘要

Objectives: The purpose of this descriptive study is to determine the significance of measurem ent of total cholesterol and low density lipoprotein(LDL)-cholesterol / high density lipoprotein(HDL)-cholesterol ratio and their association with patients of coronary artery d isea se (C AD).M eth ods: Th e lipid p ro file of 58 9 cases in clud ing pa tie nts ag ed 2 0-70 ye ars with corona ry a rtery dise ase, M l, hypercholesterolaemia and normal healthy subjects were investigated to determine the changes in total cholesterol, triglycerides, high density lipoprotein-C(HDL-C),low density lipoprotein-C(LDL-C) and LDL-C/HDL-C ratio.Enzymatic analysis was done within 24 hours using Hitachi 704 and 911 auto-analyzer. Results: As expected, LDL-C/HDL-C ratio was higher in the patient group 4(48% in females, 58.8% in males) than that in healthy group, whereas the HDL-C was lower. Moreover, the mean value of HDL-C, LDL-C and cholesterol in males was greater than that of females. The LDL-C/HDL-C ratio in hypercholesterolaemic patients(3.1, 34.7%) as less than in CAD/MI patients(4.49, 73.4%). Also this ratio in Ml group(4.9,93%) was greater than that of CAD and hypercholesterolaemic group.The mean value of HDL-C in CAD, Ml and hypercholesterolaem ic patients was less than that of control group but LDL-C was opposite. C onclusion: We found that LDL-C/HDL-C ratio is an effective indicator of high risk factor of CAD and in the management of patients suffering from hypercholesterolaemia. Also it is useful to the clinician w hen combined with detailed knowledge of the patient's other risk factors. The effect of disturbances of lipids and lipoproteins on the development of CAD and hypercholesterolaemia patients may also depend on the presence of other non-lipid risk factors.