Vasopressin, Angiotensin II and Tyrosine-Hydroxylase Expression in theHypothalamus of the Syndrome of Inappropriate ADH: A Case Report

摘要

The Syndrome of Inappropriate Antidiuretic Hormone (SIADH) is a disease characterized by hyponatremia andhyperosmolality of urine, and where vasopressin, angiotensin II and catecholamines are implicated in salt water balance,cardiovascular and blood pressure regulation. Therefore, the aim of this study is to analyze the hypothalamic distributionof vasopressin (VAS) Angiotensin II (AGII) and tyrosine-hydroxylase (TH) in a case of SIADH and compare it with acase without SIADH. Two hypothalamus taken from a 66 year-old man with SIADH, and the other from a 63 year-oldman without SIADH, were used. An immunohistochemical study was performed using anti-VAS, anti-AGII and anti-THas primary antibodies. The vasopressin immunoreactive material was mainly found in the supraoptic nucleus (SON) andparaventricular nucleus (PVN), but VAS was also shown in the periventricular nucleus, preoptic medial area, perifornicalnucleus and hypothalamic lateral area. The AGII was also mainly found in the SON and PVN. The TH was found in theSON, PVN, arcuate nucleus, periventricular nucleus, perifornical nucleus, preoptic medial and lateral area. VAS was lessintensive and in a lesser number of cells and fibres in the case of SIADH, as opposed to the AGII and TH which weresimilar in both cases.