Changes in TRP Channels Expression in Painful Conditions

摘要

Over the last fifteen years after the successful cloning of the first nociceptive Transient Receptor Potential(TRP) channel, TRP Vanilloid 1, other members of the TRP channel family have been cloned, characterized andimplicated in different modalities of pain. Tremendous progress has been made with regard to the specific role of theseTRP channels in nociception using electrophysiological and molecular methods, along with behavioral models combinedwith gene disruption techniques. This review summarizes the evidence supporting the role of TRP channels (TRPVanilloid 1, TRP Vanilloid 2, TRP Vanilloid 3, TRP Vanilloid 4, TRP Ankyrin 1, TRP Melastatin 2, TRP Melastatin 3,TRP Melastatin 8, TRP Mucolipin 3 and TRP Canonical 1, 6) involved in nociception. The review also highlights thecurrent status and future avenues for developing TRP channel modulators as analgesic agents.