The apoptotic process involved in the male reproductive system regulates the ability of the male to fertilize andpass on his genes through the process of spermatogenesis. Numerous factors are involved in mediating this essential andintricate process. It is known that without programmed cell death there would be an overwhelming amount of chaoswithin the seminiferous tubules of the testis, which would lead to dysfunctional spermatogenesis, and problems within themale reproductive system. Of the factors effecting testicular apoptosis, we are interested in studying the effects of NuclearFactor kappa B (NF-κB) as well as select cytokines as they appear to have a significant role in germ cell death. Othermediators will also be briefly discussed in this paper.
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