Long-Term Use of Intravitreal Bevacizumab (Avastin) for the Treatment of Von Hippel-Lindau Associated Retinal Hemangioblastomas

摘要

Retinal hemangioblastomas are the most common manifestation of Von Hippel-Lindau (VHL) disease [1-3].While peripheral retinal hemangioblastomas may be treated by thermal laser treatment or cryotherapy, optic nerve andmacular lesions are more difficult to treat [4, 5]. Based on the theoretical benefit of administering anti-VEGF treatment,intra-vitreally administered bevacizumab (Avastin, a general pan-VEGF inhibitor) is attractive [6, 7]. Several short-term case series using ranibizumab (Lucentis, mAb fragment of bevacizumab with stronger affinity forVEGF-A) have shown it has promising but minimal success on most VHL-related hemangioblastomas [8, 9]. Acomprehensive study by Wong et al. examined 5 patients over a period up to 61 weeks (47 ± 14 weeks) while Michels et al. examined one patient over a period of 4 months. Due to the short-term nature of these studies, we attempted long-termbevacizumab treatment over 60 months in a monocular subject with progressive visual loss due to a VHL associatedmacular and optic nerve hemangioblastoma. Over the treatment regimen of 15 injections, visual acuity improved 25letters, OCT thickness improved from 646 um to 424 um, and structural lesions stabilized while exudates and edemaresolved.