Enzymatic Antioxidants: Next Phase of Pharmacological Effort to Fight Oxidative Stress?

摘要

The focus in the research of antioxidants is notably displaced in favour of research of enzyme derivatives.Extracellular superoxide dismutase (EC-SOD) is of the particular interest, as it demonstrates in vivo the protective actionagainst development of atherosclerosis, hypertension, heart failure, diabetes mellitus. The reliable association of coronaryartery disease with the decreased level of heparin-released EC-SOD was established in clinical researches. To base anddevelop antioxidant therapy, various SOD isozymes, catalase (CAT), the methods of experimental gene therapy,combined application of SOD- and CAT-activities are used. Covalent bienzyme SOD - CHS - CAT conjugate (whereCHS - chondroitin sulphate) showed in the experimental trials its high efficacy as the antithrombotic agent. Pre-clinicalresearch data approve the reliable option to gain for it the status of drug candidate. The trend to use the components ofglycocalyx and extracellular matrix for target delivery of medical substances is evident. Development of new enzymeantioxidants for therapeutical destination is closely connected with becoming and progress of medical biotechnology,pharmaceutical industry, bioeconomy.