Non-invasive Vagus Nerve Stimulation (nVNS) as mini-prophylaxis for menstrual/menstrually related migraine: an open-label study

摘要

Menstrual migraine and menstrually related migraine attacks are typically longer, more disabling, and less responsive to medications than non-menstrual attacks. The aim of this study was to evaluate the efficacy, safety, and tolerability of non-invasive vagus nerve stimulation for the prophylactic treatment of menstrual migraine/menstrually related migraine. Fifty-six enrolled subjects (menstrual migraine, 9?%; menstrually related migraine, 91?%), 33 (59?%) of whom were receiving other prophylactic therapies, entered a 12-week baseline period. Fifty-one subjects subsequently entered a 12-week treatment period to receive open-label prophylactic non-invasive vagus nerve stimulation adjunctively (31/51; 61?%) or as monotherapy (20/51; 39?%) on day ?3 before estimated onset of menses through day +3 after the end of menses. The number of menstrual migraine/menstrually related migraine days per month was significantly reduced from baseline (mean?±?standard error, 7.2?±?0.7?days) to the end of treatment (mean?±?standard error, 4.7?±?0.5?days; P?