Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation

摘要

Original citation: J Clin Invest. 2011;121(3):941-955. https://doi.org/10.1172/JC143584 Citation for this corrigendum: J Clin Invest. 2018;128(10):4742-4743. https://doi.org/10.1172/JC1123039 The Editors recently posted an Expression of Concern for this article following notification from an investigative committee at Duke University that a research technician in the animal pulmonary physiology laboratory fabricated and/or falsified flexiVent data reported in Figures 1A, 2A, and 7D of this paper. The authors have now repeated these experiments, and the journal has published an updated online version of the article with new experimental data in Figures 1A and 2A. The airway hyperresponsiveness data in the original version of Figure 7D were not reliable, and the corrected version of the figure does not include these data. In addition, the journal has published an online version of the original article with the unreliable data crossed out (Supplemental File, Redaction). In that version, Supplemental Figure 3, which supported the original Figure 1A, is no longer referenced. The authors have provided a detailed description of the new experiments below. In our published work, we had reported that inhalable particulate allergens are more potent in causing allergic asthma than soluble allergens in sensitized mice when challenged via the airways. We based our conclusions on three independent readouts, two of which, eosinophil recruitment and histopathological examination of the lung cross sections, were undertaken in the Abraham [...