E Pluribus Unum? The Main Protein Kinase A Catalytic Subunit (PRKACA), a Likely Oncogene, and Cortisol-Producing Tumors

摘要

Perhaps the most important outcome of these studies is that a new pathway, other than steroidogenesis or the glucocorticoid receptor, emerges as a possible therapeutic target for patients with CPAs and/or other forms of hy- percortisolism and CS. Inhibitors of cAMP signaling and/or PKA and its catalytic subunits exist in vivo (PKA inhibitor) (51, 52), and it should not be hard to test small molecules that would mimic the endogenous PKA inhib- itors or identify new ones that would target the adrenal Ca overactivity in patients with CS.