The Endocrine Society Clinical Practice Guidelines: A Self-Assessment

摘要

GRADE method is the only one that rates the strength of the recommendation (Strong or Weak) based on a balance of benefits vs harms, the confidence in the magnitude of estimated effect on an outcome, and the weighing of patient values and preferences. Although this method allows for Strong recommendations to be made with low (L) or very low (VL) levels of evidence and vice versa, this should not be a frequent occurrence. TES engaged the Knowledge and Evaluation Research (KER) Unit at the Mayo Clinic to provide methodolog- ical assistance to each of the CPG expert panels, whose expertise generally is in clinical medicine and not in methodology or epidemiology.