Background: GH deficiency (GHD) is often associated with cardiovascular risk factors, including abdominal fat accumulation, hypercholesterolemia, and increased C-reactive protein. Despite the presence of these risk factors, adults with congenital lifetime isolated GHD (IGHD) due to an inactivating mutation in the GHRH receptor gene do not have premature atherosclerosis.Objective: The aim was to study the serum levels of adiponectin and leptin (antiatherogenic and atherogenic adipokine, respectively), and the urinary albumin excretion (UAE) in these IGHD individuals.Design and Patients: We conducted a cross-sectional study of 20 IGHD individuals (seven males; age, 50.8 ± 14.6 yr) and 22 control subjects (eight males; age, 49.9 ± 11.5 yr).Main Outcome Measures: Anthropometric factors, body composition, blood pressure, serum adiponectin, leptin, and UAE were measured.Results: Adiponectin was higher [12.8 (7.1) vs . 9.7 (5) ng/ml; P = 0.041] in IGHD subjects, whereas no difference was observed in leptin [7.3 (6.3) vs . 9.3 (18.7 ng/ml] and UAE [8.6 (13.8) vs . 8.5 (11.1) μg/min].Conclusions: Subjects with lifetime untreated IGHD have an adipokine profile with high adiponectin and normal leptin levels that may delay vascular damage and lesions of the renal endothelium.
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机译：背景：GH缺乏症（GHD）通常与心血管危险因素有关，包括腹部脂肪堆积，高胆固醇血症和C反应蛋白增加。尽管存在这些危险因素，但由于GHRH受体基因失活而导致先天性一生孤立GHD（IGHD）的成年人没有过早的动脉粥样硬化。目的：目的是研究血清脂联素和瘦素的水平（抗动脉粥样硬化和设计和患者：我们对20名IGHD个体（7名男性; 50.8±14.6岁）和22名对照组（20名IGHD个体）进行了横断面研究。主要结果：测量人体测量因素，身体成分，血压，血清脂联素，瘦素和阿联酋。结果：脂联素较高[12.8（7.1）vs。 9.7（5）ng / ml; P = 0.041]在IGHD受试者中，而瘦素[7.3（6.3）vs。 9.3（18.7 ng / ml）和阿联酋[8.6（13.8）vs. 8.5（11.1）μg/ min]。结论：IGHD终生未经治疗的受试者的脂肪因子谱具有高脂联素和正常瘦素水平，这可能会延迟血管损伤和病变。肾内皮。
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