EGF Receptor (ERBB1) Abundance in Adipose Tissue Is Reduced in Insulin-Resistant and Type 2 Diabetic Women

Carlyle Rogers; Fatiha Moukdar; Marie A. McGee; Barbara Davis; Benjamin M. Buehrer; Kiefer W. Daniel; Sheila Collins; Hisham Barakat; Jacques Robidoux

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EGF Receptor (ERBB1) Abundance in Adipose Tissue Is Reduced in Insulin-Resistant and Type 2 Diabetic Women

机译：胰岛素抵抗和2型糖尿病妇女脂肪组织中的EGF受体（ERBB1）丰度降低

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Context:Indications of adipose tissue dysfunction correlate with systemic insulin resistance and type 2 diabetes. It has been suggested that a defect in adipose tissue turnover may be involved in the development of these disorders. Whether this dysfunction causes or exacerbates systemic insulin resistance is not fully understood.

机译：背景：脂肪组织功能障碍的指征与全身性胰岛素抵抗和2型糖尿病相关。已经提出，脂肪组织更新的缺陷可能与这些疾病的发展有关。这种功能障碍是否会引起或加剧全身性胰岛素抵抗尚未得到充分了解。

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《The journal of clinical endocrinology and metabolism》 |2012年第3期|共12页
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Carlyle Rogers; Fatiha Moukdar; Marie A. McGee; Barbara Davis; Benjamin M. Buehrer; Kiefer W. Daniel; Sheila Collins; Hisham Barakat; Jacques Robidoux;
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1. Increased adiposity and reduced adipose tissue mRNA expression of uncoupling protein-2 in first-degree relatives of type 2 diabetic patients: evidence for insulin stimulation of UCP-2 and UCP-3 gene expression in adipose tissue. [J] . Pedersen SB, Nyholm B, Kristensen K, Diabetes, obesity & metabolism . 2005,第1期

机译：2型糖尿病患者一级亲属中肥胖的增加和解偶联蛋白2的脂肪组织mRNA表达降低：胰岛素刺激脂肪组织中UCP-2和UCP-3基因表达的证据。
2. Upregulation of adiponectin receptor 1 and 2 mRNA and protein in adipose tissue and adipocytes in insulin-resistant women with polycystic ovary syndrome [J] . B. K. Tan, J. Chen, J. E. Digby, Diabetologia . 2006,第11期

机译：多囊卵巢综合征胰岛素抵抗女性脂肪组织和脂肪细胞脂联素受体1和2 mRNA和蛋白的上调
3. Android subcutaneous adipose tissue topography in lean and obese women suffering from PCOS: Comparison with type 2 diabetic women [J] . R. Horejsi, R. Moller, S. Rackl, American Journal of Physical Anthropology . 2004,第3期

机译：患有PCOS的肥胖和肥胖女性的Android皮下脂肪组织地形图：与2型糖尿病女性的比较
4. Effects of body weight restriction on blood and adipose tissue adipokines and macrophage activation in obese and insulin-resistant ponies [C] . J. Ungru, M. Blither, M. Coenen, European Workshop on Equine Nutrition . 2012

机译：体重限制对血液和脂肪组织的影响肥胖和胰岛素抗性小马血吸虫和巨噬细胞活化
5. Lipoprotein Receptor SR-B1 Deficiency Enhances Adipose Tissue Inflammation and Reduces Susceptibility to Hepatic Steatosis During Diet-Induced Obesity in Mice [D] . ?Rivera Vega, Katherine Solange 2020

机译：脂蛋白受体SR-B1缺乏增强脂肪组织炎症，并在小鼠饮食诱导的肥胖期间减少对肝脏脂肪变性的易感性
6. Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects. [O] . F Ahmad, R V Considine, B J Goldstein 1995

机译：受体型蛋白质酪氨酸磷酸酶LAR的丰度增加说明了肥胖人受试者的脂肪组织中胰岛素受体的去磷酸化活性提高。
7. EGF Receptor (ERBB1) Abundance in Adipose Tissue Is Reduced in Insulin-Resistant and Type 2 Diabetic Women [O] . Carlyle Rogers, Fatiha Moukdar, Marie A. McGee, 2012

机译：在胰岛素抗性和2型糖尿病女性中，脂肪组织中的EGF受体（ERBB1）丰度降低

EGF Receptor (ERBB1) Abundance in Adipose Tissue Is Reduced in Insulin-Resistant and Type 2 Diabetic Women

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