Antifibrinolytics: e-Aminocaproic acid, Tranexamic Acid and Aprotinin

摘要

Introduction Pharmacologic approaches to reduce bleeding and transfusion in cardiac surgical patients are based on either preventing the defects associated with the cardiopulmonary bypass CPB induced coagulopathy. Different pharmacologic agents have been reported, however the currently accepted pharmacologic interventions are based on using a protease inhibitor, aprotinin, or lysine analogs to inhibit fibrinolysis. These agents will be reviewed.