Bacteria Meningitis: Problems Of Empirical Treatment In A Teaching Hospital In The Tropics

摘要

Bacteria meningitis (BM) is commonly associated with high fatality. This study was conducted in Ladoke Akintola University Teaching Hospital, Osogbo, Nigeria, with the view to assessing the outcome and usefulness of empirical therapy of BM. Medical records of patients with BM managed in the year 2004 and 2005 were retrieved and demographic, clinical and laboratory data obtained analyzed using GraphPad computer software. Records of 172 patients were available for analysis; age range was 1day - 80 years, M: F ratio 1.7: 1. Mortality rate was 45.6%; 38.3% had favourable outcome, 8.1% had varying neurological sequelae and 11.5% discharged self against medical advice. Cerebrospinal fluid (CSF) analysis was done in only 68 patients; 30 had CSF parameters suggestive of BM; Gram stain was positive for bacteria in only 18 (26.5%) and culture in 6 (8.9%). Outcome was poorer in dehydrated patients (P=0.032), cases without CSF investigations (P=0.0001), and those who did not receive antibiotics (P=0008). The only empiric antibiotic combination with significant favourable outcome was penicillinG and chloramphenicol (P=0.021). This result shows that empirical treatment of BM is associated with high case fatality. Introduction Since the first recognition of bacteria meningitis (BM) in 18051, mortality from this infection has remained unacceptably high and developmental disabilities and neurologic sequelae following neonatal and infantile meningitis still occur in significant number of survivals. Specific aetiological diagnosis of BM in developing countries is often difficult. Although Gram staining of CSF sediment is a very useful cheap and fairly rapid method of identification of organism, the sensitivity in developing countries is only 25-40%2 when compared to 80-85% in developed countries3. Cultures of CSF are also infrequently performed in many health institutions in developing countries and sensitivity does not exceed 40% with results available only after 2-3days2,4. Other methods such as latex antigen tests (LAT)5 and polymerase chain reaction (PCR)6 that are highly sensitive and specific are expensive and not available for routine use in developing countries.In Nigeria, epidemics of meningitis due to Neisseria meningitidis have been reported from the Northern region since the 1950s7,8,9,10,11,12, and in the South, epidemic and sporadic cases13,14,15,16,17,18 of BM due to Streptococcus pneumoniae, Haemophilus influenzae and enteric Gram negative bacilli have been reported by different tertiary health institutions. Several reviews19,20,21 have suggested that the choice of antimicrobial agent for the initial empiric therapy of bacterial meningitis when there is no CSF Gram stain result or when CSF Gram stain is not diagnostic, should depend on the age, geographical location and immunological status of the patient. In many tertiary health institutions in Nigeria, financial constraints have compelled many clinicians to employ empiric therapy for patients with meningitis without CSF analysis or culture. In this study, we assess the use of empiric therapy for suspected BM in our institution in order to determine its suitability in a resource poor country. Materials And Method Medical records of 172 patients clinically diagnosed and managed as BM in Ladoke Akintola University Teaching Hospital, Osogbo, between 2004 and 2005 were retrieved for analysis. Information retrieved included demographic data, height, weight, presenting complaints, results of physical examination, predisposing factors, complications, outcome and problems encountered during management. In those investigated, results of microbiological and other laboratory investigations were also retrieved.Data entry and management were done with Microsoft Excel on IBM ThinkPad computer. All analyses and calculations were performed using GraphPad software (GraphPad Software Inc, San Diego, USA). Relationship between categorical variables was done using Chi square or Fisher's exact test