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Ancient Schwannoma Of The Nasal Cavity, A Rare Cause Of Nasal Obstruction: A Review And Case Report

机译:古代鼻腔神经鞘瘤,一种罕见的鼻阻塞原因:回顾与病例报告

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Schwannomas with destructive pathologic characteristics, also known as ancient schwannomas are slow growing benign tumours arising from the nerve sheath. Approximately one third of schwannomas occur in the head and neck region. Surgery is the treatment of choice and total excision is curative. Although schwannomas have been described in the head and neck region, we would like to report, to the best of our knowledge, the first case of an ancient schwannoma of the nasal cavity. Introduction Scwannomas are benign, encapsulated tumours arising from the Schwan cells of the nerve sheath, and were originally described by Stout in 1935 [1]. Batsakis more accurately described these tumours as neurilemmomas, in reference to the cells of origin [2]. Approximately 25-40% of all neurilemmomas occur in the head and neck region [3]. The acoustic nerve is the most frequent site involved. Other locations described in the literature include the scalp, oral cavity, pharynx, larynx, parotid gland, middle ear and sinonasal tract. [4, 5] Sinonasal tract schwannomas are very rare, representing less than 4% of head and neck schwannomas. [6] Patients, with sinonasal schwannomas, ages range from 12 to 76 years, with most cases occurring between ages 25 and 55 years. Males and females are affected equally. [7]Symptoms and signs associated with sinonasal schwannomas include rhinorrhea, epistaxis, anosmia, and facial swelling. [8] Because these tumours are located in a cavity, they are able to grow silently to a substantial size before diagnosis. The most common affected area is the ethmoid sinus, followed by the maxillary sinus, nasal pits, and sphenoid sinus. [8] Localization to the nasal septum is exceedingly rare. [9] This paper reports an unusual case of an Ancient Schwannoma that presented as long standing nasal obstruction. Case presentation A 54 year old gentleman presented to our outpatients department complaining of a blocked nose for the past three years. He stated that his left nostril was more blocked than the right and that it was progressively getting worse. He did not have any nasal discharge, discomfort or epistaxis. He also did not have any other systemic complaints.On examination he was a healthy looking gentleman and examination of his throat, ears and neck did not reveal any abnormalities. On examination of his nose an obvious mass in the left nostril could be seen, displacing the septum to the right side. The mass appeared pale and granular.A contrasted CT scan of his nose and sinuses were done. The scan revealed a large soft tissue mass lesion that completely filled the left nasal cavity. It showed irregular, mild enhancement post contrast. The mass had completely obliterated the nasal turbinates and osteo-meatal opening on the left side and extended posteriorly as far as the posterior choanae on the left. The nasopharynx was normal. The nasal septum was markedly deviated to the right side. The appearance was suggestive of a slow growing mass (Figure 1,2) . The differential diagnosis included benign nasal polyp, inverting papilloma and schwannoma.
机译:具有破坏性病理特征的神经鞘瘤,也称为古代神经鞘瘤,是由神经鞘引起的生长缓慢的良性肿瘤。约三分之一的神经鞘瘤发生在头部和颈部。手术是治疗的选择,完全切除是治愈的。尽管在头部和颈部区域描述了神经鞘瘤,但据我们所知,我们还是要报道第一例鼻腔神经鞘瘤的病例。引言斯旺氏肉瘤是由神经鞘的Schwan细胞引起的良性,包囊性肿瘤,最初由Stout在1935年描述[1]。 Batsakis参照起源细胞更准确地将这些肿瘤描述为神经瘤[2]。大约25-40%的神经膜瘤发生在头颈部区域[3]。声神经是最常见的部位。文献中描述的其他位置包括头皮,口腔,咽,喉,腮腺,中耳和鼻窦道。 [4,5]鼻鼻窦神经鞘瘤非常罕见,仅占头颈部神经鞘瘤的4%。 [6]鼻窦神经鞘瘤患者的年龄范围为12至76岁,大多数病例发生在25至55岁之间。男性和女性受到同等影响。 [7]与鼻窦神经鞘瘤相关的症状和体征包括鼻漏,鼻epi,失眠和面部肿胀。 [8]由于这些肿瘤位于腔中,因此能够在诊断之前静默生长到相当大的大小。最常见的感染区域是筛窦,其次是上颌窦,鼻凹和蝶窦。 [8]定位于鼻中隔非常罕见。 [9]本文报道了一个古老的神经鞘瘤的罕见病例,该病例表现为长期鼻塞。病例介绍一位54岁的绅士向我们的门诊诊治,抱怨过去三年中鼻子被阻塞。他说,他的左鼻孔比右鼻孔受阻更大,并且逐渐变得越来越糟。他没有任何鼻涕,不适或鼻epi。他也没有其他系统的不适。检查时他是一个健康的绅士,检查他的嗓子,耳朵和脖子没有发现任何异常。在检查他的鼻子时,可以看到在左鼻孔中有明显的肿块,使隔膜向右侧移位。肿块显得苍白且呈颗粒状,对他的鼻子和鼻窦进行了CT对比扫描。扫描显示较大的软组织块病变完全充满了左鼻腔。对比后显示不规则,轻度增强。该肿块已完全消除了左侧的鼻甲和骨肉开口,并向后延伸至左侧的后鼻孔。鼻咽正常。鼻中隔明显偏向右侧。外观提示肿块生长缓慢(图1,2)。鉴别诊断包括良性鼻息肉,倒置性乳头状瘤和神经鞘瘤。

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