Cell density and cortical thickness in Heschl’s gyrus in schizophrenia, major depression and bipolar disorder

摘要

There is evidence that the superior temporal gyrus and Heschla€?s gyrus within it are implicated in schizophrenia. We investigated neuronal and glial cell density and cortical thickness within Heschla€?s gyrus, using the optical disector to estimate cell density within cortical layers 3 and 5 in tissue derived postmortem from people with diagnoses of major depressive disorder, schizophrenia and bipolar disorder, compared with normal controls ( n =15 per group). No significant difference in neuronal or glial cell density or in cortical thickness was observed between the groups; our findings therefore provide no support for the presence of cellular pathology within Heschla€?s gyrus in schizophrenia.