SCREENING AND TLC-BIOAUTOGRAPHY ANALYSIS OF ANTIMICROBIAL COMPOUNDS FROM SOME SPONGE EXTRACTS ORIGINATED FROM BARRANG LOMPO SEA ISLAND, SOUTH SULAWESI

摘要

Sponges is one of the invertebrate Porifera phyla that produce active compounds with various structures and one of the biological activity as antimicrobial. The purpose of this research was to find out the sponge extracts that can inhibit microbial growth and potential of antimicrobial active compounds from sponge at Barrang Lompo Island. The microbes used were Escherichia coli , Salmonella typhii , Staphylococcus aureus , and Candida albicans . The sponge extracts were obtained by maceration 14 sponge samples with methanol, followed by partition using chloroform and methanol, then TLC-bioautography toward the active extract. The results showed that methanol extracts of sponge with code BRLP-009 and 010 have the most potential effect as antimicrobial agent.