This paper reports an analytical method for the determination of ambroxol in micellar medium by spot test-diffuse reflectance spectroscopy. The reflectance measurements were performed analyzing the colored compound (λ= 520 nm) produced from the reaction between ambroxol and p-dimethylaminocinnamaldehyde on the surface filter paper. The linear range was from 1.21 × 10"3 to 9.65 × 10"3 mol L-1 (500 - 4000 μg mL-1). The limit of detection and quantification were 3.50 x 10-4 mol L-1 (145 μg mL-1) and 1.16 x 10-3 mol L-1 (481 μg mL-1), respectively. Five commercial samples were analysed and the results obtained by the proposed method were in good agreement with those obtained by the literature method at 95% confidence level.
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机译：本文报道了一种通过斑点测试-漫反射光谱法测定胶束介质中氨溴索的分析方法。通过分析在表面滤纸上由氨溴索与对二甲氨基肉桂醛之间的反应产生的有色化合物（λ= 520 nm）进行反射率测量。线性范围从1.21×10“ 3到9.65×10” 3 mol L-1（500-4000μgmL-1）。检测和定量的极限分别为3.50 x 10-4 mol L-1（145μgmL-1）和1.16 x 10-3 mol L-1（481μgmL-1）。分析了五个商业样本，通过该方法获得的结果与通过文献方法获得的结果在置信度为95％时非常吻合。
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